Hyaluronidase 10 vials

Hyaluronidase

The enzyme that dissolves hyaluronic acid is called hyaluronidase, and hyaluronidase is an alkaline protein. Its main function is for those who seek beauty but are dissatisfied with the results of hyaluronic acid shaping. Hyaluronidase is an effective agent for dissolving hyaluronic acid. For example, some individuals who have undergone hyaluronic acid injections may not achieve the desired filling effect. In such cases, hyaluronidase can be used to dissolve the injected hyaluronic acid under the skin. After that, hyaluronic acid can be reapplied for modification and filling. Hyaluronidase serves as an auxiliary tool, allowing for timely adjustments if one is unsatisfied after hyaluronic acid filling.

Hyaluronidase is an alkaline protein secreted by phagocytes and is sensitive to Gram-positive bacteria. The effects of injection are typically visible around 20 minutes after the procedure. If the amount of injected hyaluronic acid is unknown when administering the hyaluronidase, a small amount is injected initially. After waiting for about 20 minutes, careful observation is required. If the dissolution is insufficient, additional hyaluronidase can be injected, and the process continues as necessary. It is important to avoid injecting too much at once, as excessive amounts may not only dissolve hyaluronic acid but also affect normal dermal and subcutaneous tissues irreversibly, causing damage to the skin.

Therefore, when using hyaluronidase, the dosage must be carefully controlled. It is crucial to avoid injecting excessive amounts at once. Simultaneously, the injection process should be closely observed to prevent complications. This ensures that normal tissues are not inadvertently dissolved, preventing disputes and disagreements among individuals seeking beauty after the procedure. Generally, the medication takes 1 to 2 days to gradually dissolve, and it is fully absorbed around 2 weeks. However, individual body conditions and recovery periods vary. The speed of recovery is closely related to each person's metabolism, making the duration of the recovery period unique to each individual.

The injection method of Hyaluronidase is as follows:

1.Identify the Injection Area: Determine the area where the hyaluronic acid needs to be dissolved and mark it accordingly.

2.Cleanse the Skin: Prior to injection, ensure that the skin is clean to reduce the risk of infection.

3.Local Anesthesia (Optional): Depending on the situation, local anesthesia may be applied to the injection area to alleviate pain.

4.Inject Hyaluronidase: Administer an appropriate amount of hyaluronidase solution by injection into the region with hyaluronic acid filler. The depth and quantity of the injection depend on the type of hyaluronic acid, the injection area, and the amount to be dissolved.

5.Massage: Post-injection, the medical professional may gently massage the injection area to help disperse hyaluronidase and facilitate the dissolution of hyaluronic acid.

6.Observation and Adjustment: After the injection, the doctor will observe the patient's reaction and may make adjustments as necessary.

It's important to note that the injection of hyaluronidase should be performed by a qualified medical professional or an experienced healthcare provider to ensure safety and effectiveness. Additionally, patients receiving injection treatments may require appropriate pre- and post-care. Consultation with a doctor before undergoing treatment is advisable for detailed advice and information.

The use of hyaluronidase:

Step 1: Standard Dilution Method for Hyaluronidase

Mix 1 bottle of hyaluronidase (1500U) with 1ml of normal saline solution. (2ml or 3ml can also be used) Inject the normal saline solution or lidocaine into the bottle, ensuring thorough dissolution of the powder.

Use a 1ml syringe to draw 0.1ml (0.2ml or 0.3ml) of the dissolved hyaluronidase.

Add normal saline solution or lidocaine to dilute the drawn solution to 1ml. Mix thoroughly, resulting in a solution containing 150U of hyaluronidase in 1ml. This 1ml solution is generally sufficient to dissolve 1ml of low molecular weight hyaluronic acid. However, for products with high cross-linking, the concentration of hyaluronidase may need to be increased. Avoid direct use of the undiluted solution as it may have excessively high concentration. The specific amount to be used depends on the requirement (refer to the table below), but the single dose should not exceed 1500U.

The prepared hyaluronidase solution is highly unstable in water; hence, it is recommended to prepare it just before use. The remaining solution can be stored at temperatures below 30 degrees Celsius for up to 2 weeks. However, if there is any discoloration or precipitation, the solution should not be reused.

Step 2: Skin Test

Before using hyaluronidase, an allergy test is necessary.

Inject 0.02ml of the drug solution with a concentration of 150U/ml intradermally.

If within 5 minutes, a pseudo foot (please search online for what a pseudo foot is) or a rash block appears, lasting for 20-30 minutes with an itching sensation, it is considered a positive result.

Note: If only a transient red rash appears locally due to blood vessel dilation, it is not considered a positive reaction.

If a positive reaction occurs, characterized by the presence of a pseudo foot and other described symptoms, injection should be abandoned.

(If a positive result is observed, please refrain from proceeding with the injection.)

Step 3: Injection

When performing the injection, first determine the depth and range of the injection. Try to inject into the middle of the hyaluronic acid, ensuring a uniform injection from multiple directions. This helps prevent uneven surfaces after dissolution.

If the depth cannot be accurately determined, it is advisable to inject more superficially, reaching the subcutaneous layer. Rely on the medication to permeate downwards; this can effectively dissolve most of the hyaluronic acid.

Precautions:

Injection of hyaluronidase should be performed under the guidance of a professional doctor. Excessive injection may lead to swelling and other adverse effects. Prior to injecting hyaluronidase, a skin test must be conducted. If symptoms such as redness, nausea, vomiting, dizziness, accelerated heartbeat, or decreased blood pressure occur, it indicates an allergic reaction. Discontinue the medication promptly and employ supportive therapy. In emergencies, epinephrine, corticosteroids, and antihistamines can be used for first aid.

1.Injection of hyaluronic acid enzyme is contraindicated within 48 hours of injecting botulinu1m toxin, as hyaluronic acid enzyme may cause significant dispersion of the toxin.

2.Avoid use in individuals with acute or chronic diseases, those taking certain medications, especially those with a history of allergies.

3.The interval between injecting hyaluronidase and subsequently injecting hyaluronic acid should typically be one week for safety. In urgent situations, the interval can be reduced to 72 hours, depending on the drug absorption conditions.

4.Adverse reactions are rare, with less than 1/1000 patients reporting hives or vascular edema.

5.A skin test is recommended before using any hyaluronic acid enzyme product.

6.Avoid use in individuals with allergies, especially those allergic to bee venom.

7.Adrenaline, benzodiazepines, and heparin are incompatible with hyaluronic acid enzyme. Salicylates, corticosteroids, estrogen, adrenocorticotropic hormones, and anti-histamines can partially weaken the enzyme-promoting effect of hyaluronic acid enzyme.

8.Not suitable for use in reducing swelling (e.g., bites, stings).

9.Not suitable for use in enhancing the absorption of dopamine or alpha-agonist antidepressants.

10.Not suitable for use in infections or inflammation and peripheral site injections (may promote the spread of infection).

11.Contraindicated in individuals with malignant tumors in the eye area.

12. Avoid use in pregnant women.